Mitochondrial longevity, NAD+ metabolism, and cellular senescence. Covers the NAMPT salvage pathway, sirtuin activation, and epigenetic aging mechanisms.
Resveratrol's reputation as a 'SIRT1 activator' for longevity is one of the most commercially successful stories in supplements. A 2025 meta-analysis of 11 human trials found the core mechanism doesn't hold up the way the story suggests.
Spermidine has a genuinely compelling mechanism and encouraging population data. But the best-powered, longest human trial to date — 12 months, 100 participants — was null on its primary cognitive endpoint. Both facts matter.
Harvard's buried 2023 study on age reversal. What 2,200+ tracked cases reveal about NAD+, epigenetic aging, and the celebrity IV infusion scam.
Most people taking NAD+ supplements don't know they're doing it wrong. 85% of your NAD+ comes from the salvage pathway—a recycling system almost nobody optimizes. The enzyme NAMPT is the key.
You're spending hundreds on supplements. But are they working? This 90-day protocol uses CGMs and bloodwork to prove what's moving the needle—and what's not.
