The Absorption Problem
Most supplements pass through
without reaching your cells
The conventional supplement industry has a foundational problem: bioavailability. A 500 mg tablet of curcumin may deliver as little as 0.86 μg/L to your bloodstream — the same dose in liposomal form delivers 32.75 μg/L. The active ingredient is identical. The dose is identical. But the molecular packaging determines what you actually absorb.
This is why Moana Natura's formulations use liposomal delivery — a technology developed from pharmaceutical drug delivery science, now applied to nutritional supplementation. Every active compound is encapsulated within phospholipid bilayer vesicles that protect it through digestion and release it directly into the bloodstream.
To validate this technology, our GMP-certified German production lab — our liposomal technology partner — conducted ten independent, randomised, controlled human clinical trials between 2018 and 2024, each comparing their liquid liposomal formulation against commercially available non-liposomal alternatives at identical doses.
Each study measured blood plasma concentrations over time and calculated the Oral Bioavailability Value (OBV) — the definitive measure of what the body actually absorbs. The results below form the scientific foundation of our formulations.
Delivery Mechanism
LipoSone™ Liposomal
Technology Explained
Liposomes are microscopic spherical vesicles composed of the same phospholipid bilayers that form human cell membranes. The active ingredient is encapsulated inside, shielded from gastric acid and enzymatic degradation during digestion.
How LipoSone™ reaches your cells
Our lab's LipoSone™ technology uses advanced liposomal encapsulation. Unlike tablet or powder forms that must survive the harsh digestive environment intact, liposomal formulations use the body's own membrane-fusion mechanisms to deliver compounds directly into cells — the same mechanism by which nutrients naturally cross cell membranes.
Active compound encapsulated in phospholipid bilayer vesicle in aqueous solution.
Protected vesicle survives gastric acid and enzymatic degradation in the digestive tract.
Phospholipid shell merges with intestinal cell membranes, releasing payload directly into bloodstream.
Clinical Data Summary
Oral Bioavailability Value
Across All 10 Compounds
The OBV is calculated by comparing the incremental area under the plasma concentration-time curve (iAUC) of the liposomal versus non-liposomal group. An OBV of 5 Times means the body absorbs 5 times as much of the active compound over the dosing period.
| Iron (vs powder) | 397.7 Times | |
| Glutathione | 63.62 Times | |
| Curcumin | 46.79 Times | |
| Iron (vs tablet+VitC) | 44.4 Times | |
| Vitamin K2 | 37 Times | |
| NADH | 22 Times | |
| Vitamin D3 | 12.84 Times | |
| Quercetin | 11.6 Times | |
| Magnesium | 5.18 Times | |
| Vitamin B12 | 4 Times | |
| Zinc (ascorbate) | 3.82 Times | |
| Coenzyme Q10 | 2.83 Times | |
| Zinc (gluconate) | 2.73 Times |
* Iron OBV vs powder (397.7 Times) and vs tablet with added Vitamin C (44.4 Times). All other OBVs vs non-liposomal tablet/pill at identical dose. Source: GMP-certified German production lab, 2018–2024.
Study Library
Ten Randomised
Controlled Human Trials
Each study enrolled 11–40 metabolically healthy volunteers, randomly assigned to liposomal or non-liposomal groups. Blood samples analysed using validated mass spectrometry and chromatography techniques.
Curcumin
- —After 2 hrs: plasma levels 30 Times higher than non-liposomal
- —After 4 hrs: both groups reach maximum plasma concentration
- —After 6 hrs: non-liposomal returns to baseline; liposomal sustained
- —Maintained elevated curcuminoid levels for full 6-hr study period
250 mg curcuminoids · n=20 · 2020
Glutathione
- —After 3 days: liposomal group significantly higher vs baseline
- —After 7 days: plasma GSH doubled; non-liposomal tablet unchanged
- —Linear plasma GSH increase maintained throughout 7-day study
- —Non-liposomal tablet showed no significant increase at any timepoint
500 mg GSH · n=20 · 2019
Iron
- —397.7 Times higher bioavailability vs non-liposomal powder iron (15 mg)
- —44.4 Times higher vs tablet Iron + Vitamin C at 40 mg dose
- —Non-liposomal forms: serum ferritin statistically unchanged from baseline
- —Liposomal group: continuous near-linear ferritin rise over 12 hrs
15 mg liposomal iron saccharate · n=30 · 2021
NADH
- —After 1 hr: significant increase in liposomal group; tablet unchanged
- —After 4 hrs: liposomal peaked; tablet remained at baseline levels
- —Maintained elevated NADH serum levels throughout 12-hr study
- —NADH instability in water makes tablet delivery near-ineffective
50 mg NADH · n=20 · 2021
Vitamin D3 + K2
- —Serum 25(OH)D3: 12.84 Times higher bioavailability vs non-liposomal tablet
- —Plasma K2-MK7: 37 Times higher bioavailability vs non-liposomal tablet
- —After 2 hrs: liposomal group significantly higher on both vitamins
- —Liposomal D3+K2 maintained elevated levels throughout full 6-hr study
1000 IU D3 + 200 μg K2-MK7 · n=20 · 2020
Quercetin
- —After 1 hr: liposomal rising steadily; non-liposomal already at maximum
- —After 6 hrs: liposomal almost 10 Times higher than non-liposomal group
- —After 12 hrs: liposomal plasma values constant and high; non-liposomal at baseline
- —Liposomal maintained elevated plasma quercetin for full 12-hr window
250 mg quercetin · n=20 · 2020
Coenzyme Q10
- —After 3 hrs: liposomal plasma CoQ10 over 60% higher than tablet
- —After 6 hrs: liposomal group 3.2 Times higher than non-liposomal group
- —Maintained significantly elevated ubiquinol levels for 12 hrs
- —C_max: 3.31 μg/L liposomal vs 0.93 μg/L non-liposomal
100 mg ubiquinol · n=20 · 2024
Magnesium
- —After 2 hrs: liposomal above reference range; standard tablet below
- —Standard 400 mg tablet unable to reach normal serum Mg reference range
- —Liposomal Mg maintained within reference range for entire 12-hr study
- —C_max: 1.14 nmol/L liposomal vs 0.83 nmol/L non-liposomal
400 mg magnesium · n=20 · 2020
Vitamin B12
- —Liposomal B12: 42% increase in cobalamin; competitor pill: only 10%
- —After 1 hr: 19% higher cobalamin and 37% higher holo-transcobalamin
- —Cobalamin levels followed near-linear increase over 5-hr study period
- —Non-liposomal pill showed only slight increase in plasma levels
2500 μg methylcobalamin · n=11 · 2018
Zinc
- —Liposomal zinc ascorbate: 3.82 Times higher vs powder zinc ascorbate
- —Liposomal zinc gluconate: 2.73 Times higher vs powder zinc gluconate
- —After 8 hrs: significant gap between liposomal and powder groups
- —Liposomal groups sustained elevated and steady plasma Zn for 12 hrs
25 mg zinc · n=40 · 2021
Scientific Standards
Rigorous Methodology
Consistent Across All Studies
Randomised & controlled
All studies were randomised, controlled two-group (or multi-group) trials. Participants randomly and evenly assigned to supplementation groups.
View study design →Strict exclusion criteria
Participants aged 20–50 years, BMI 18.5–24.9 kg/m², no chronic conditions, no current medication or supplement use.
Pharmacokinetic analysis
Blood samples at fasted baseline, then 1–12 hour intervals post-dose. Analysed via LC/MS-MS, mass spectrometry, or validated colorimetric assays.
AUC calculation
AUC₀₋ₜ calculated using trapezoidal rule. iAUC adjusts for baseline variation. OBV = liposomal iAUC ÷ non-liposomal iAUC.
OBV methodology →Independent clinical sites
Studies conducted at Surya Research Clinics, New Delhi (9 studies) and Dr. Heidrich und Kollegen GmbH, Hamburg (B12 study).
EU-manufactured formulas
All liposomal test formulations manufactured by our GMP-certified German production lab, Hamburg, Germany, to GMP standards.
Regulatory Standards
EFSA-Approved
Health Claims
All health claims on Moana Natura products are substantiated by the European Food Safety Authority. EFSA evaluates scientific evidence through rigorous peer review — only those with proven clinical backing receive approval.
Omega-3 (EPA & DHA)★ EFSA“EPA and DHA contribute to the normal function of the heart. Beneficial effect obtained with 250 mg EPA and DHA daily.”
EU Reg. No 432/2012 · Authorised health claim
Vitamin D3★ EFSA“Vitamin D contributes to the maintenance of normal bones, teeth, muscles, and normal immune system function.”
EU Reg. No 432/2012 · Authorised health claim
Vitamin K2 (MK-7)★ EFSA“Vitamin K contributes to normal bone maintenance and to normal blood clotting.”
EU Reg. No 432/2012 · Authorised health claim
Magnesium★ EFSA“Magnesium contributes to normal protein synthesis, normal muscle function, and reduction of tiredness and fatigue.”
EU Reg. No 432/2012 · Authorised health claim
Iron★ EFSA“Iron contributes to normal cognitive function, red blood cell formation, haemoglobin synthesis, and oxygen transport.”
EU Reg. No 432/2012 · Authorised health claim
Zinc★ EFSA“Zinc contributes to normal immune function, normal cognitive function, and protection of cells from oxidative stress.”
EU Reg. No 432/2012 · Authorised health claim
Chromium★ EFSA“Chromium contributes to maintenance of normal blood glucose levels and to normal macronutrient metabolism.”
EU Reg. No 432/2012 · Authorised health claim
Citations