Mitochondrial longevity, NAD+ metabolism, and cellular senescence. Covers the NAMPT salvage pathway, sirtuin activation, and epigenetic aging mechanisms.
NAD+ is one of the most consequential molecules in the human body — central to how every cell generates energy, repairs itself, and responds to stress. Here's the biology behind why it declines with age, and why that decline matters.
Quercetin is one of the most extensively researched flavonoids in nutrition science, with a genuine antioxidant and anti-inflammatory evidence base. It's also part of a closely watched combination in early-stage cellular-aging research — here's how the two stories fit together.
NR reliably raises NAD+ levels in the blood — that part is well established. Whether that translates into a measurable health outcome is a separate, much less settled question, and the honest answer matters more than the marketing shortcut.
Resveratrol's reputation as a 'SIRT1 activator' for longevity is one of the most commercially successful stories in supplements. A 2025 meta-analysis of 11 human trials found the core mechanism doesn't hold up the way the story suggests.
Spermidine is a naturally occurring compound your body already produces and encounters in foods like wheat germ and aged cheese. Its role in cellular renewal has a genuinely compelling scientific story — here's what's behind it.
Harvard's buried 2023 study on age reversal. What 2,200+ tracked cases reveal about NAD+, epigenetic aging, and the celebrity IV infusion scam.
Most people taking NAD+ supplements don't know they're doing it wrong. 85% of your NAD+ comes from the salvage pathway—a recycling system almost nobody optimizes. The enzyme NAMPT is the key.
You're spending hundreds on supplements. But are they working? This 90-day protocol uses CGMs and bloodwork to prove what's moving the needle—and what's not.
