Energy & Cellular Defense
Precision NAD+ and cellular energy support. Clinically dosed for European biology.
VAT included • Free EU shipping over €65 • Cancel subscription anytime
Express Checkout
Every ingredient at clinical dosage. No proprietary blends. No fillers. Full transparency.
Sirtuin Activator
Direct SIRT1 activation, enhancing NAD+ utilization efficiency
NAD+ Precursor — EU Authorized Novel Food
Enters cells via NRK1/NRK2 kinase — directly synthesising NMN then NAD+, bypassing the rate-limiting NAMPT step that limits plain Nicotinamide. Superior cellular bioavailability.
Commission Implementing Regulation (EU) 2020/16
"Authorized Novel Food at 300 mg/day for adults"
Enzymatic Cofactor
Essential cofactor for 300+ enzymes including DNA repair
EFSA Journal 2009;7(9):1229
"Contributes to the protection of cells from oxidative stress"
CD38 Inhibitor
Inhibits CD38 enzyme that degrades NAD+, extending NAD+ half-life
How SirtCore™ 01 optimizes your cellular energy metabolism through precision targeting
Nicotinamide Riboside (NR) enters cells via the NRK1/NRK2 kinase pathway — converting directly to NMN and then NAD+, bypassing the rate-limiting NAMPT step that constrains plain Nicotinamide.
Trans-Resveratrol directly activates SIRT1 genes — the master regulators of cellular longevity and mitochondrial biogenesis.
Quercetin inhibits CD38, the enzyme responsible for 95% of NAD+ degradation. This extends NAD+ half-life significantly.
Zinc Bisglycinate serves as an essential cofactor for 300+ enzymes, including those in DNA repair and Sirtuin function.
The Result: Optimized NAD+ levels, enhanced mitochondrial function, and activated cellular defense mechanisms.
See how targeted formulation compares to broad-spectrum approaches
| Feature | SirtCore™ 01 | AG1 | Seed DS-01 | Generic Multi |
|---|---|---|---|---|
| Ingredient Count | 4 (Precision) | 75+ | 24 | 20-30 |
| Precision Dosing | ||||
| EFSA Compliant | Full | Partial | Yes | Varies |
| Direct NAD+ Support | Yes — NR 300mg (EU 2020/16) | Indirect | No | Minimal |
| Sirtuin Activation | ||||
| CD38 Inhibition | ||||
| Formula Transparency | Full Disclosure | Proprietary Blends | Full Disclosure | Varies |
| Price | €49 | €99 | €60 | €10-25 |
We publish the regulatory basis for every ingredient. Here is why SirtCore™ 01 uses NR, not NMN.
Nicotinamide Mononucleotide (NMN) is classified as a Novel Food under Regulation (EU) 2015/2283. It has not received an authorization decision from the European Commission and cannot legally be sold as a food supplement in the EU.
Regulation (EU) 2015/2283 — Novel Food, no authorization issued
Nicotinamide Riboside (NR) was granted Novel Food authorization by the European Commission under Commission Implementing Regulation (EU) 2020/16 for use in food supplements at up to 300 mg per day for the general adult population. SirtCore™ 01 delivers the full authorized dose.
Commission Implementing Regulation (EU) 2020/16 — 10 January 2020
Nicotinamide (B3) — Limited Pathway
Relies on NAMPT — a rate-limiting enzyme that becomes a bottleneck under supplemental doses. High-dose Nicotinamide can also inhibit Sirtuins through feedback mechanisms.
Nicotinamide Riboside (NR) — Direct Route ✓
Enters cells via NRK1/NRK2 kinase — a direct, high-capacity route to NMN and then NAD+. No NAMPT bottleneck. Does not inhibit Sirtuins at supplemental doses.
References: Commission Implementing Regulation (EU) 2020/16 · Regulation (EU) 2015/2283 · Bogan & Brenner 2008 (NRK pathway) · Canto et al. 2012 (NR bioavailability) · EFSA Journal 2009;7(9):1229
GMP Certified
Germany
Third-Party Tested
Independent Verification
Made in Germany
GMP Certified Facility
EFSA Compliant
Full Documentation
Supplements support your biology — they do not override it. Realistic timelines build sustainable results.
Your body establishes baseline levels of the active compounds. No specific outcome is expected at this stage — consistent dosing is building the foundation.
Take at the same time each day to support consistent bioavailability.
With consistent use alongside a healthy diet and exercise, customers often report noticing changes. Biomarker shifts are possible during this window. Individual results vary.
Results depend on diet, sleep, exercise, and individual genetics.
Sustained, consistent use allows the full protocol to function as intended. Most customers who see the clearest benefits use for a minimum of 90 days.
This is precision nutrition — not a pharmaceutical. Protocol duration matters.
Individual results vary based on diet, exercise, lifestyle, sleep quality, and individual genetics. This is not a pharmaceutical — it is precision nutrition. Results are not guaranteed.
The ingredients are selected based on clinical evidence and EFSA-approved health claims. Supplements support healthy biological function — they do not replace diet, exercise, and sleep. Use consistently alongside a healthy lifestyle for the best outcomes.
Timeline varies by individual. With consistent use, many customers report noticing changes within 4–8 weeks. A full 90-day protocol is recommended for sustained benefit. Individual results depend on diet, exercise, genetics, and consistency.
EFSA regulates health claims, not ingredients. All ingredients in this formula are authorised for use in EU food supplements. Every health claim we make is approved under EU Regulation 432/2012 or EFSA Regulation 1924/2006. EFSA Journal references are listed on each product page and verifiable at efsa.europa.eu.
We don't make comparative claims — EU Regulation 1924/2006 prohibits them without rigorous substantiation. What we do: clinical doses of EFSA-approved ingredients, full ingredient transparency, and proactive compliance monitoring. You can verify every claim we make.
Four compounds. Clinical dosages. Full EU compliance. Precision-targeted formulation for cellular energy support.
Food Supplement. This product is not intended to diagnose, treat, cure, or prevent any disease. Manufactured in Germany in accordance with EFSA standards. Do not exceed recommended daily intake. Keep out of reach of children. Store in a cool, dry place. Consult your healthcare provider before use if you are pregnant, nursing, taking medication, or have a medical condition.
